Publications

Age-specific regulation of sociability by hypothalamic Agrp neurons (opens in new tab)

Iyilikci O, Kim L, Zimmer MR, Bober J, Li Y, Pelts M, Santana GM, Dietrich MO

Current Biology 35(18):4522–4536.e6 · doi:10.1016/j.cub.2025.08.014 (opens in new tab)

Erratic maternal care induces avoidant-like attachment deficits in a mouse model of early life adversity (opens in new tab)

MacDowell Kaswan ZA, Bowers C, Teplyakov I, Sibtain A, Munoz-Martin J, Ahmed S, Kaffman L, Giuliano L, Dietrich MO, Kaffman A

eNeuro 12(11) · doi:10.1523/ENEURO.0249-25.2025 (opens in new tab)

What makes each of us unique? The nine-banded armadillo as a model to study individuality (opens in new tab)

Leão DP, Duque A, Dietrich MO

Frontiers in Mammal Science 3:1450655 · doi:10.3389/fmamm.2024.1450655 (opens in new tab)

Neurons for infant social behaviors in the mouse zona incerta (opens in new tab)

Li Y, Liu ZW, Santana GM, Capaz AM, Doumazane E, Gao XB, Renier N, Dietrich MO

Science 385(6707):409–416 · doi:10.1126/science.adk7411 (opens in new tab)

SqueakOut: autoencoder-based segmentation of mouse ultrasonic vocalizations (opens in new tab)

Santana GM, Dietrich MO

bioRxiv (preprint) 2024.04.19.590368 · doi:10.1101/2024.04.19.590368 (opens in new tab)

Immune sensing of food allergens promotes avoidance behaviour (opens in new tab)

Florsheim EB, Bachtel ND, Cullen JL, Lima BGC, Godazgar M, Carvalho F, et al. Dietrich MO, Medzhitov R

Nature 620(7974):643–650 · doi:10.1038/s41586-023-06362-4 (opens in new tab)

Development of "Hunger Neurons" and the unanticipated relationship between energy metabolism and mother–infant interactions (opens in new tab)

Iyilikci O, Zimmer MR, Dietrich MO

Biological Psychiatry 91(10):907–914 · doi:10.1016/j.biopsych.2022.02.962 (opens in new tab)

AgRP neurons control structure and function of the medial prefrontal cortex (opens in new tab)

Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, et al.

Molecular Psychiatry 27(10):3951–3960 · doi:10.1038/s41380-022-01691-8 (opens in new tab)

Deficiency of the paternally inherited gene Magel2 alters the development of separation-induced vocalization and maternal behavior in mice (opens in new tab)

Bosque Ortiz GM, Santana GM, Dietrich MO

Genes, Brain and Behavior 21(1):e12776 · doi:10.1111/gbb.12776 (opens in new tab)

Analysis of ultrasonic vocalizations from mice using computer vision and machine learning (opens in new tab)

Fonseca AHO, Santana GM, Bosque Ortiz GM, Bampi S, Dietrich MO

eLife 10:e59161 · doi:10.7554/eLife.59161 (opens in new tab)

VocalMat — open-source USV analysis tool.

Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding (opens in new tab)

Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y, et al. Dietrich MO, Chen MH, Xu Y, Wu Q

Nature Communications 12(1):3525 · doi:10.1038/s41467-021-23846-x (opens in new tab)

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice (opens in new tab)

Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, et al. Dietrich MO, et al.

eLife 10:e66522 · doi:10.7554/eLife.66522 (opens in new tab)

AgRP neurons control compulsive exercise and survival in an activity-based anorexia model (opens in new tab)

Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL

Nature Metabolism 2(11):1204–1211 · doi:10.1038/s42255-020-00300-8 (opens in new tab)

Regulation of substrate utilization and adiposity by Agrp neurons (opens in new tab)

Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO

Nature Communications 10(1):311 · doi:10.1038/s41467-018-08239-x (opens in new tab)

Activation of Agrp neurons modulates memory-related cognitive processes in mice (opens in new tab)

Zimmer MR, Schmitz AE, Dietrich MO

Pharmacological Research 141:303–309 · doi:10.1016/j.phrs.2018.12.024 (opens in new tab)

Functional ontogeny of hypothalamic Agrp neurons in neonatal mouse behaviors (opens in new tab)

Zimmer MR, Fonseca AHO, Iyilikci O, Dai Pra R, Dietrich MO

Cell 178(1):44–59.e7 · doi:10.1016/j.cell.2019.04.026 (opens in new tab)

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages (opens in new tab)

Pereira MMA, Mahú I, Seixas E, Martinéz-Sánchez N, Kubasova N, Pirzgalska RM, Cohen P, Dietrich MO, López M, Bernardes GJL, Domingos AI

Nature Communications 8:14967 · doi:10.1038/ncomms14967 (opens in new tab)

Plasticity of calcium-permeable AMPA glutamate receptors in pro-opiomelanocortin neurons (opens in new tab)

Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL

eLife 6:e25755 · doi:10.7554/eLife.25755 (opens in new tab)

Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding (opens in new tab)

Dietrich MO, Zimmer MR, Bober J, Horvath TL

Cell 160(6):1222–1232 · doi:10.1016/j.cell.2015.02.024 (opens in new tab)

AgRP neurons regulate bone mass (opens in new tab)

Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL

Cell Reports 13(1):8–14 · doi:10.1016/j.celrep.2015.08.070 (opens in new tab)

Hypothalamic POMC neurons promote cannabinoid-induced feeding (opens in new tab)

Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, et al. Dietrich MO, Gao XB, Diano S, Horvath TL

Nature 519(7541):45–50 · doi:10.1038/nature14260 (opens in new tab)

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding (opens in new tab)

Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, et al. Dietrich MO, Tschöp MH, Horvath TL

Nature Neuroscience 17(7):908–910 · doi:10.1038/nn.3725 (opens in new tab)

O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat (opens in new tab)

Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, et al. Horvath TL, Yang X

Cell 159(2):306–317 · doi:10.1016/j.cell.2014.09.010 (opens in new tab)

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity (opens in new tab)

Dietrich MO, Liu ZW, Horvath TL

Cell 155(1):188–199 · doi:10.1016/j.cell.2013.09.004 (opens in new tab)

Hypothalamic control of energy balance: insights into the role of synaptic plasticity (opens in new tab)

Dietrich MO, Horvath TL

Trends in Neurosciences 36(2):65–73 · doi:10.1016/j.tins.2012.12.005 (opens in new tab)

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar (opens in new tab)

Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, et al. Friedman JM

eLife 2:e01462 · doi:10.7554/eLife.01462 (opens in new tab)

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry (opens in new tab)

Hess ME, Hess S, Meyer KD, Verhagen LAW, Koch L, Brönneke HS, Dietrich MO, et al. Brüning JC

Nature Neuroscience 16(8):1042–1048 · doi:10.1038/nn.3449 (opens in new tab)

Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses (opens in new tab)

Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, et al. Dietrich MO, Horvath TL

PNAS 110(15):6193–6198 · doi:10.1073/pnas.1210644110 (opens in new tab)

Neuroimmunology

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance (opens in new tab)

Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, et al. Horvath TL, Zorzano A, Claret M

Cell 155(1):172–187 · doi:10.1016/j.cell.2013.09.003 (opens in new tab)

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation (opens in new tab)

Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG

Cell Metabolism 15(2):247–255 · doi:10.1016/j.cmet.2011.12.016 (opens in new tab)

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons (opens in new tab)

Dietrich MO, Horvath TL

Nature Reviews Drug Discovery 11(9):675–691 · doi:10.1038/nrd3739 (opens in new tab)

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors (opens in new tab)

Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL

Nature Neuroscience 15(8):1108–1110 · doi:10.1038/nn.3147 (opens in new tab)

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes (opens in new tab)

Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, et al. Chowen JA

Journal of Clinical Investigation 122(11):3900–3913 · doi:10.1172/JCI64102 (opens in new tab)

Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center (opens in new tab)

Horvath TL, Abizaid A, Dietrich MO, Li Y, Takahashi JS, Bass J

Molecular Metabolism 1(1–2):79–85 · doi:10.1016/j.molmet.2012.08.003 (opens in new tab)

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism (opens in new tab)

Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, et al. Tschöp MH

Physiological Reviews 92(3):1479–1514 · doi:10.1152/physrev.00022.2011 (opens in new tab)

Obesity is associated with hypothalamic injury in rodents and humans (opens in new tab)

Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Schwartz MW

Journal of Clinical Investigation 122(1):153–162 · doi:10.1172/JCI59660 (opens in new tab)

Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity (opens in new tab)

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, et al. Horvath TL

Nature Medicine 17(9):1121–1127 · doi:10.1038/nm.2421 (opens in new tab)

Synaptic plasticity of feeding circuits: hormones and hysteresis (opens in new tab)

Dietrich MO, Horvath TL

Cell 146(6):863–865 · doi:10.1016/j.cell.2011.08.031 (opens in new tab)

Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance (opens in new tab)

Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL

Journal of Neuroscience 30(35):11815–11825 · doi:10.1523/JNEUROSCI.2234-10.2010 (opens in new tab)