Dietrich Lab

From our laboratory
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Pereira MM, Mahú I, Seixas E, Martinéz-Sánchez N, Kubasova N, Pirzgalska RM, Cohen P, Dietrich MO, López M, Bernardes GJ, Domingos AI*. Nat Commun. 2017 Apr 3;8:14967. doi: 10.1038/ncomms14967.

Rapid shift in substrate utilization driven by hypothalamic Agrp neurons.
Cavalcanti-de-Albuquerque JP, Zimmer MR, Bober J, Dietrich MO*. bioRxiv. Nov 7; doi: PDF

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding.
Dietrich MO*, Zimmer MR, Bober J, Horvath TL. Cell. 2015 Mar 12; 160:1-11. doi:10.1016/j.cell.2015.02.024. PDF

Previous Publications

(for publications before 2012, click on PUBMED and SCHOLAR links above)

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL.Elife. 2017 Aug 1;6. pii: e25755. doi: 10.7554/eLife.25755. PDF

Hypothalamic POMC neurons promote cannabinoid-induced feeding.
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Nature. 2015 Feb 18. doi: 10.1038/nature14260. PDF

AgRP Neurons Regulate Bone Mass.
Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. Cell Rep. 2015 Oct 6;13(1):8-14. doi: 10.1016/j.celrep.2015.08.070. PDF

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat.
Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. Cell. 2014 Oct 9;159(2):306-17. PDF

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Nat Neurosci. 2014 Jun 1. PDF

Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice. Dietrich MO, Antequera D, Pascual C, Castro N, Bolos M, Carro E. ​J Alzheimers Dis. 2014;39(4):711-7. PDF

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, de Araujo IE, Friedman JM. Elife. 2013 Dec 31;2:e01462. PDF

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Dietrich MO, Liu ZW, Horvath TL. Cell. 2013 Sep 26;155(1):188-99. PDF

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M. Cell. 2013 Sep 26;155(1):172-87. PDF

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC. Nat Neurosci. 2013 Aug;16(8):1042-8. doi: 10.1038/nn.3449. PDF

Visualizing browning in vivo. Dietrich MO. Mol Metab. 2013 Jul 17;2(3):126-7. PDF

High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice. Muller AP, Dietrich MO, Martimbianco de Assis A, Souza DO, Portela LV. Longev Healthspan. 2013 Jun 3;2(1):10. PDF

Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6193-8. PDF

Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Dietrich MO, Horvath TL. Trends Neurosci. 2013 Feb;36(2):65-73. PDF

A marriage made to last in drug design. Dietrich MO, Horvath TL. Nat Med. 2012 Dec;18(12):1737-8.

​Phosphoribosomes for fingerprinting neurons. Dietrich MO, Horvath TL. Cell. 2012 Nov 21;151(5):934-6.

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. J Clin Invest. 2012 Nov 1;122(11):3900-13.

UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. PLoS One. 2012;7(8):e42911.

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Dietrich MO, Horvath TL. Nat Rev Drug Discov. 2012 Sep;11(9):675-91.

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Physiol Rev. 2012 Jul;92(3):1479-514.

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL. Nat Neurosci. 2012 Jun 24;15(8):1108-10.

Fat incites tanycytes to neurogenesis. Dietrich MO, Horvath TL. Nat Neurosci. 2012 Apr 25;15(5):651-3. PubMedAgRP neurons: the foes of reproduction in leptin-deficient obese subjects.Dietrich MO, Horvath TL. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2699-700.

​Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Cell Metab. 2012 Feb 8;15(2):247-55.

Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. Horvath TL, Abizaid A, Dietrich MO, Li Y, Takahashi JS, Bass J. Mol Metab. 2012 Aug 18;1(1-2):79-85.

​Obesity is associated with hypothalamic injury in rodents and humans. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. J Clin Invest. 2012 Jan 3;122(1):153-62.